The exact mechanism of action of isoniazid is unknown, but it is thought to prevent the tuberculosis bacteria from making substances called mycolic acids, which are needed to form the cell walls of the bacteria.
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3 , 13 15 treatment with isoniazid for nine months diminishes the rate of reactivation during granuloma dissolution, providing an effectiveness rate of approximately 90 percent in compliant patients.
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they may also hide certain signs of low blood sugar and make it more difficult to notice angiotensin-converting enzyme ace inhibitors eg, enalapril , azole antifungals eg, miconazole, ketoconazole , chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors maois eg, phenelzine , nonsteroidal anti-inflammatory drugs nsaids eg, ibuprofen , phenylbutazone, probenecid, quinolone antibiotics eg, ciprofloxacin , salicylates eg, aspirin , and sulfonamides eg, sulfamethoxazole because the risk of low blood sugar may be increased calcium channel blockers eg, diltiazem , corticosteroids eg, prednisone , decongestants eg, pseudoephedrine , diazoxide, diuretics eg, furosemide, hydrochlorothiazide , estrogens, hormonal contraceptives eg, birth control pills , isoniazid, niacin, phenothiazines eg, promethazine , phenytoin, rifamycins eg, rifampin , sympathomimetics eg, albuterol, epinephrine , or thyroid supplements eg, levothyroxine because they may decrease duetact s effectiveness, resulting in high blood sugar gemfibrozil because blood sugar may be increased or decreased anticoagulants eg, warfarin because their effectiveness may be decreased or the risk of their side effects may be increased by duetact.
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myambutol-inh ethambutol hydrochloride has reduced the incidence of the emergence of mycobacterial resistance to isoniazid when both drugs have been used concurrently.
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if you have ever had to stop taking rhea isoniazid for any reason.
More than a half-century later, isoniazid continues to be on the front line of the battle against tb.
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